Endocrine Abstracts

Background: Impaired mitophagy (mitochondrial autophagy) and NLRP3 inflammasome activation have been implicated in the etiopathogenesis of insulin resistance and T2DM. Metformin beside being an insulin-sensitizer, also induces autophagy. However, further research is warranted in elucidating its effect on mitophagy and NLRP3 activation in patients with T2DM.Methods: 45 drug-naïve, newly diagnosed T2DM patients, with HbA1C 53–75 mmol/m...